Mission Hope Cancer Center
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Clinical Trials Newsletter

Achievements in the Fight Against Cancer

Driven by a vision, Mission Hope Cancer Center has an abiding commitment to fight against cancer. As part of our commitment to providing the most thorough care, Mission Hope participates in clinical trials through our affiliation with UCLA and major pharmaceutical and biotechnology companies. Because we believe that patients should have access to as many treatment options as possible, our board certified oncologists include state-of-the art clinical trials as another option. The range of choices has expanded dramatically for patients: new drugs, updated drug delivery methods and immunotherapy—which assists your own immune system in fighting the illness—are part of what we offer at the Mission Hope Cancer Center.




1st Line- A Randomized, Double –Blind, Placebo-Controlled, Phase 3 study of non-steroidal aromatase inhibitors ( Anastrozole or Letrozole) plus LY2835219, a CDK4/6 inhibitor, or placebo in women with hormone receptor positive, HER2 negative locally advanced or metastatic breast cancer who have not received prior systemic therapy for locally advanced or metastatic disease.

1st Line- A randomized open-label Phase 2 study of Letrozole plus Afatinib (BIBW2992) vs Letrozole alone in 1st line treatment of advanced ER+, HER2- post menopausal breast cancer with low ER expression.

1st Line-A Phase 2/3 Multi-Center, Open-Label, Randomized study of weekly Nab-Paclitaxel in combination with Gemcitabine or Carboplatin compared with Gemcitabine/Carboplatin as 1st line treatment in subjects with ER-, PR-, HER2 – (Triple Negative) metastatic breast cancer.

2nd /3rd Line- Phase 2 randomized trial of Mugard compared with best supportive care for prevention and treatment of stomatitis in women with hormone receptor positive breast cancer initiating treatment with Everolimus-based endocrine therapy.

NeoAdjuvant- A randomized, Multicenter, Open-Label, Two-Arm, Phase 3 NeoAdjuvant Study evaluating Trastuzumab Emtansine and Pertuzumab alone or in combination with chemotherapy for patients with HER2 positive breast cancer.

2nd/3rd Line- Phase 1b/2 single-arm trial evaluating the combination of Lapatinib, Everolimus and Capecitabine for the treatment of patients with HER2-positive metastatic breast cancer with CNS progression after Trastuzumab. BREAST – HER2 POSITIVE (continued)

3rd Line- A study of Neratinib + Capecitabine vs Lapatinib + Capecitabine in patients with HER2+ metastatic breast cancer who have received 2 or more prior HER2- directed regimens in the metastatic setting (NALA) 3rd Line- An observational cohort study of treatment patterns and outcomes in patients with HER2 Positive (HER2+) metastatic breast cancer.

BREAST ( Her 2 positive & negative)
2nd Line- A Phase 2, randomized, open-label, multicenter, safety and efficacy study of oral Lucatinib in patients with FGF aberrant metastatic breast cancer.

2nd/3rd Line- A Phase 3, Open-Label, Randomized, Parallel, 2-Arm study of BMN 673 vs physician’s choice in germline BRCA mutation subjects with locally advanced and/or metastatic breast cancer, who have received no more than 2 prior chemotherapy regimens for metastatic breast disease.

3rd Line- A Phase 2, Two-stage, 2-cohort study of BMN673 administered to germline BRCA mutation subjects with locally advanced and/or metastatic breast cancer.


2ND Line- Open-label, multi-center, randomized Phase1b/2 study to assess the efficacy, safety and tolerability of PF-05212384 + 5FU-Leucovorin-Irinotecan (FOLFIRI) compared to Bevacizumab + FOLFIRI.


1st Line- TIGER 1: A randomized, Open-Label, Phase 2 study of CO-1686 or Erlotinib as 1st line treatment of patients with EGFR-Mutant Advanced Non-Small Cell Lung Cancer(NSCLC).

1st Line- A randomized Open-Label Phase 3 trial of MK-3475 vs Platinum based chemotherapy in subjects with PD-L1 strong metastatic Non-Small Cell Lung Cancer

2nd Line- A Phase 3b/4 Safety trial of Nivolumab (BMS-936558) in subjects with advanced or metastatic Non-Small Cell Lung Cancer who have progressed during or after receiving at least 1 prior systemic regimen.

2nd/3rd Line-A Phase 3, open-label, multicenter, randomized study to investigate the efficacy and safety of MPDL3280A (anti-PD-11 antibody) compared with Docetaxel in patients with NSCLC after Platinum failure

2nd/3rd Line-A Phase 1B Dose-Escalation study of Pemetrexed and AUY922 in previously-treated patients with metastatic Non Squamous, Non-Small Lung Cancer.

3rd Line- A Randomized phase 3 study of LY2835219 + best supportive care vs Erlotinib + best supportive care in patients with stage 4 NSCLC with a detectable KRAS Mutation who have progressed after Platinum-based chemotherapy.

3rd Line-Lung cancer molecular profiling and clinical outcomes in U.S. community oncology practices.


2ND/3RD Line- A Phase 3 , randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of GS-1101 (CAL-101) in combination with Rituxumab for previously treated Indolent Non-Hodgkin Lymphoma

Multiple Myeloma

2nd/3rd Line- A Phase I/II study of Pomalidomide, Dexamethasone & Pegylated Liposomal Doxorubicin for patients with relapsed/refractory Multiple Myeloma. Must have failed Revlimid.


Maintenance- A multi-center, randomized, double-blind, placebo-controlled, phase 3 study of Rucaparib as switch maintenance therapy following Platinum-based chemotherapy.


2ND Line- A Randomized, Double-Blind, Phase 3 study of the JAK1/2 Inhibitor, Ruxolitinib or placebo in combination with Capecitabine in subjects with advanced or metastatic adenocarcinoma of the pancreas who have failed or are intolerant to 1st line chemotherapy.


Prospective Observational study of Patients with primary Polycythemia Vera in U.S. clinical practices.